منابع مشابه
Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury.
Previously it was shown that urine from patients with nephritis contains podocytes and their fragments (podocalyxin [PCX]-positive granular structures [PPGS]), reflecting the degree of podocyte injury. The present study was designed to trace PPGS to their origin. Urine samples and renal biopsy specimens from 53 children with nephrotic syndrome and nephritis were examined immunohistochemically. ...
متن کاملPodocyte injury can be catching.
Podocyte loss is a central mediator of glomerular sclerosis. Because podocytes are terminally differentiated cells that lack the potential to proliferate, they are particularly vulnerable to attrition in response to critical levels of cell stress, leading to detachment, necrosis, or apoptosis. Just how much podocyte loss is necessary to generate an initial sclerotic lesion and whether injury ca...
متن کاملTacrolimus Protects Podocytes from Injury in Lupus Nephritis Partly by Stabilizing the Cytoskeleton and Inhibiting Podocyte Apoptosis
OBJECTIVE Several studies have reported that tacrolimus (TAC) significantly reduced proteinuria in lupus nephritis (LN) patients and mouse models. However, the mechanism for this effect remains undetermined. This study explored the mechanism of how TAC protects podocytes from injury to identify new targets for protecting renal function. METHODS MRL/lpr mice were given TAC at a dosage of 0.1 m...
متن کاملAcute podocyte injury is not a stimulus for podocytes to migrate along the glomerular basement membrane in zebrafish larvae
Podocytes have a unique 3D structure of major and interdigitating foot processes which is the prerequisite for renal blood filtration. Loss of podocytes leads to chronic kidney disease ending in end stage renal disease. Until now, the question if podocytes can be replaced by immigration of cells along the glomerular basement membrane (GBM) is under debate. We recently showed that in contrast to...
متن کاملActivation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?
The renal podocyte plays an important role in maintaining the structural integrity of the glomerular basement membrane. We have previously reported that patients with idiopathic nephrotic syndrome (INS) have increased IL-2 production. We hypothesized that podocytes express an IL-2 receptor (IL-2R) and signaling through this receptor can result in podocyte injury. To confirm the presence of the ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2011
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2010090963